Suhagra 100 mg is a brand name for sildenafil citrate, a medication primarily used to treat erectile dysfunction (ED) in men. Its mechanism of action is based on its ability to increase blood flow to the penis, facilitating an erection when combined with sexual stimulation.

Here’s a breakdown of its mechanism of action:

Inhibition of Phosphodiesterase Type 5 (PDE5):
Suhagra 100 mg works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which is present in the smooth muscle cells of the penis. Under normal conditions, PDE5 breaks down cyclic guanosine monophosphate (cGMP), a molecule responsible for relaxing the smooth muscles in the blood vessels of the penis.

Increased cGMP Levels:
When PDE5 is inhibited, cGMP levels increase. Elevated cGMP levels promote the relaxation of smooth muscles in the blood vessels, allowing them to dilate (widen). This dilation increases blood flow into the penis, which is essential for achieving and maintaining an erection.

Enhanced Erection Response to Sexual Stimulation:
The presence of sexual stimulation is still required for sildenafil to work. When a man is sexually aroused, nitric oxide (NO) is released in the penis, which activates the enzyme guanylate cyclase, leading to increased production of cGMP. By inhibiting PDE5, sildenafil helps to preserve the action of cGMP, allowing a more sustained and enhanced erection.

Duration and Onset of Action:
Suhagra 100 mg typically begins to work within 30 to 60 minutes of ingestion, and its effects can last for up to 4-6 hours. However, it does not increase sexual desire and will only help with erectile function when sexual arousal occurs.

To summarize, Suhagra 100 mg works by inhibiting PDE5, leading to increased cGMP levels in the penile smooth muscles, which promotes blood flow and allows for an erection in response to sexual stimulation.