Zhewitra 10 mg contains Vardenafil, used primarily to treat erectile dysfunction (ED). When considering interactions with antidepressants, it's crucial to note potential interactions with medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). These interactions can sometimes lead to a condition called serotonin syndrome, which is rare but serious.

It's advisable to consult with a healthcare provider before combining Zhewitra 10mg with antidepressants to ensure safety and avoid potential adverse effects. Healthcare providers can assess individual health conditions, medications, and potential interactions to determine the best course of treatment.